Alterations in NMDA receptor subunit levels in the brain regions of rats chronically administered typical or atypical antipsychotic drugs |
| |
| Authors: | Hanaoka Tadahito Toyoda Hirotaka Mizuno Takafumi Kikuyama Hiroki Morimoto Kazushige Takahata Ryuichi Matsumura Hitoshi Yoneda Hiroshi |
| |
| Affiliation: | (1) Department of Neuropsychiatry, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-City, Osaka, 569-8686, Japan;(2) Laboratory Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-City, Osaka, 569-8686, Japan |
| |
| Abstract: | It has been hypothesized that glutamatergic neurotransmission is related to the therapeutic effect of antipsychotic drugs. To test this hypothesis, we measured by use of the Western blot technique the polypeptide levels of NMDA receptor subunits, that is, NMDAR1, 2A, 2B, and 2C, in several regions of the rat brain after chronic treatment with haloperidol (HPD) or clozapine (CLZ). Each rat was intraperitoneally injected with HPD or CLZ at 10:00 h daily for 14 days. The brain regions examined were frontal cortex, striatum, nucleus accumbens, hippocampus, and cerebellum. Decreases in the polypeptide level of NMDAR2B were seen in hippocampus (but not in other brain regions) following the treatment with HPD or CLZ. Altered levels in NMDAR1-, 2A-, and 2C were not detected in any brain regions examined. We infer that an alteration in NMDAR2B in hippocampus is related to therapeutic effects of antipsychotic drugs. |
| |
| Keywords: | Western blotting antipsychotic drug haloperidol clozapine NMDA receptor rat brain |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
