Tintinnadiol,a sphaeroane diterpene from fruiting bodies of Mycena tintinnabulum |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;1. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA;2. Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA;3. Northwestern University Feinberg School of Medicine, Department of Molecular Pharmacology and Biological Chemistry, Chicago, IL 60611, USA;4. Center for Structural Genomics of Infectious Diseases (CSGID) |
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| Abstract: | Antifungal metabolites were isolated from fruiting bodies of Mycena tintinnabulum and from mycelia grown in either complex media or on oak wood. Strobilurins were produced in fruiting bodies and in mycelial cultures, whereas a new diterpene, named tintinnadiol, was isolated only from the fruiting bodies. The structure of the new compound was determined by spectroscopic methods. It exhibited cytotoxic effects. |
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