|
|||||
|
|
Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth |
|
| Authors: | Janecka Anna Fichna Jakub Kosson Piotr Zalewska-Kaszubska Jadwiga Krajewska Urszula Mirowski Marek Rozalski Marek |
| Affiliation: | a Department of Medicinal Chemistry, Medical University, Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland b Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland c Department of Pharmacodynamics, Medical University, Lodz, Poland d Department of Pharmaceutical Biochemistry, Medical University, Lodz, Poland |
| Abstract: | In the present study, we reported on the synthesis of two new mu-opioid peptide analogs, [D-1-Nal3]morphiceptin and [D-1-Nal4]-morphiceptin [1-Nal=3-(1-naphthyl)-alanine] which expressed receptor binding affinities at least at the level of the primary opioid ligands. The new analogs also labeled mu-opioid receptors on the cells of human breast cancer MCF-7 cell line with affinity much higher than that of endomorphins and morphiceptin, the well-known mu-selective opioid peptides. However, none of the tested peptides significantly decreased cell proliferation of MCF-7 cells. |
| Keywords: | Morphiceptin Endomorphin-1 and -2 Peptide analogs Antiproliferative effects Binding studies |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |