| 中脑导水管周围灰质内注射抗阿片肽血清对神经降压素增强电针镇痛的影响 |
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| 引用本文： | 白波,王宏,刘文彦,宋朝佑. 中脑导水管周围灰质内注射抗阿片肽血清对神经降压素增强电针镇痛的影响[J]. 生理学报, 1999, 0(2) |
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| 作者姓名： | 白波 王宏 刘文彦 宋朝佑 |
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| 作者单位： | 1. 济宁医学院神经生理研究室,济宁,272113
2. 第二军医大学神经生物学教研室,上海,200433 |
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| 摘 要： | 本工作以钾离子透入引起大鼠甩尾反应作为痛反应指标，观察纳洛酮（ＮＸ）和抗阿片肽血清对大鼠中脑导水管周围灰质（ＰＡＧ）内微量注射神经降压素（ＮＴ）增强电针镇痛作用的影响。结果显示：（１）ＰＡＧ内微量注射ＮＴ后，大鼠电针镇痛效应明显提高；（２）ＰＡＧ内注射大剂量ＮＸ，可以显著减弱ＮＴ增强电针镇痛效应；（３）ＰＡＧ内微量注射抗甲脑啡肽血清和抗β内啡肽血清后，ＮＴ增强电针镇痛的作用明显降低；而ＰＡＧ内微量注射抗强啡肽Ａ１１３血清，对于ＮＴ增强电针镇痛的作用并无明显影响。提示：ＰＡＧ内ＮＴ在针刺镇痛过程中发挥重要作用，ＮＴ增强电针镇痛的作用与甲脑啡肽和β内啡肽有较密切的关系。
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| 关 键 词： | 神经降压素；中脑导水管周围灰质；电针镇痛；抗甲-脑啡肽血清；抗β-内啡肽血清；抗强啡肽A_(1-13)血清 |
EFFECT OF ANTI-OPIOID PEPTIDE SERA ON THE ENHANCEMENT OF ELECTROACUPUNCTURE ANALGESIA INDUCED BY NEUROTENSIN IN PAG OF RATS |
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| BAI BO,WANG HONG,LIU WEN-YAN,SONG CHAO-YOU. EFFECT OF ANTI-OPIOID PEPTIDE SERA ON THE ENHANCEMENT OF ELECTROACUPUNCTURE ANALGESIA INDUCED BY NEUROTENSIN IN PAG OF RATS[J]. Acta Physiologica Sinica, 1999, 0(2) |
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| Authors: | BAI BO WANG HONG LIU WEN-YAN SONG CHAO-YOU |
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| Abstract: | With the use of potassium iontophoresis induced tailflick for measuring the pain threshold, the effects of injecting neurotensin (NT), naloxone (NX), antimetenkephalin serum (AMEKS), antiendorphin serum (AEPS) and antidynorphin A113 serum (ADYNS) into periaqueductal gray (PAG) on electroacupuncture (EA) analgesia in rats were investigated. NT administration enhanced EA analgesia remarkably. Preinjection of NX, AMEKS and AEPS into PAG could significantly attenuate the enhancement of EA analgesia induced by NT , but not by administration of ADYNS. The results indicate that NT in PAG is responsable for the enhancement of EA analgesia. The effect of NT may be partly mediated by metenkephalin and endorphin. |
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| Keywords: | neurotensin periaquedutal gray electroacupuncture analgesia antimetenkephalin serum antiendorphin serum antidynorphin A113 serum |
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