The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species |
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Authors: | Clare K Schmitt Stephen C Darnell Alison D O'Brien |
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Institution: | Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences F. Edward Hèbert School of Medi ine, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA |
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Abstract: | Abstract FlgM inhibits the flagella-specific sigma factor FliA and is involved in the mouse-virulence of Salmonella typhimurium . In recent experiments, we observed that: (i) a flgM gene that could function to negatively regulate flagella synthesis was present in a variety of salmonellae; and (ii) the flgM gene derived from Salmonella species that are not normally virulent in mice could complement the S. typhimurium flgM mutant for virulence. Our results suggest that a functional flgM , has been retained in most, and perhaps all, Salmonella species, regardless of the motility or virulence phenotype of the strain. |
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Keywords: | Salmonella Virulence Regulation Flagella flgM |
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