The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans |
| |
Authors: | Wells Christine A Salvage-Jones Judith A Li Xin Hitchens Kelly Butcher Suzanne Murray Rachael Z Beckhouse Anthony G Lo Yu-Lan-Sandra Manzanero Silvia Cobbold Christian Schroder Kate Ma Bo Orr Sally Stewart Lauren Lebus Daniel Sobieszczuk Peter Hume David A Stow Jennifer Blanchard Helen Ashman Robert B |
| |
Institution: | National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia. |
| |
Abstract: | The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|