Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin |
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| Authors: | R N Sifers F D Ledley L Reed-Fourquet D H Ledbetter S A Ledbetter S L Woo |
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| Affiliation: | Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030. |
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| Abstract: | A cDNA encoding the complete open reading frame of murine alpha 1-antitrypsin has been cloned and sequenced. The nucleic acid and predicted amino acid sequences show homology to human alpha 1-antitrypsin and demonstrate the preservation of critical structural determinants for intracellular targeting, carbohydrate attachment, and catalytic function. The alpha 1-antitrypsin gene locus (Aat) has been localized on murine chromosome 12E----F by in situ hybridization. |
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