Ryanodine inhibits calcium transients evoked by action potentials in a subpopulation of rat dorsal root ganglion neurons |
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Authors: | A Shmigol' |
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Institution: | (1) International Center for Molecular Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine;(2) Department of Physiology of University of Cologne, Germany |
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Abstract: | Effects of ryanodine on calcium transients evoked by depolarization of external membrane under voltage clamp conditions or by a train of action potentials under current clamp conditions were studied on isolated dorsal root ganglion neurons of newborn rats. In 70% neurons tested, ryanodine, a blocker of Ca2+-induced Ca2+ release from endoplasmic reticulum, significantly decreased the amplitude of calcium transients. The data obtained indicate that the Ca2+-induced Ca2+ release plays an important role for calcium signal generation in a subpopulation of sensory neurons.Neirofiziologiya/Neurophysiology, Vol. 26, No. 6, pp. 420–422, November–December, 1994. |
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