Melatonin enhances Th2 cell mediated immune responses: Lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists |
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Authors: | Raghavendra Vasudeva Singh Vinod Kulkarni Shrinivas K Agrewala Javed N |
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Institution: | (1) Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India;(2) Immunology Laboratory, Institute of Microbial Technology, Sector39A Chandigarh, India |
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Abstract: | Chronic administration of melatonin for 5 days to antigen-primed mice increased the production of pro-inflammatory cytokine IL10 but decreased the secretion of antiinflammatory cytokine TNF-. These results further confirm that melatonin activates Th2like immune response. Whether melatoninmediated Th2 response is dependent on opioid or central and peripheral benzodiazepine receptors was also examined. Hence, melatonin was administered to antigen-sensitised mice with either naltrexone (a opioid receptor antagonist) or flumazenil (a central benzodiazepine receptor antagonist) or PK11195 (a peripheral benzoidiazepine receptor antagonist). No significant difference in melatonin-induced Th2 cell response was observed by naltrexone, flumazenil or PK11195 treatment. These findings suggest that the Th2 cell response induced by melatonin in antigen sensitised mice neither dependent on endogenous opioid system nor is modulated through the central or peripheral benzodiazepine receptors. |
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Keywords: | melatonin Th1//Th2 cells IL4" target="_blank">gif" alt="dash" align="MIDDLE" BORDER="0">4 IFNgif" alt="dash" align="MIDDLE" BORDER="0">" target="_blank">gif" alt="gamma" align="MIDDLE" BORDER="0"> IgG1 IgG2a endopioids central/peripheral benzodiazepine receptors |
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