| 穿心莲内酯等中药有效成分对表皮葡萄球菌生物膜渗透性的比较 |
| |
| 引用本文： | 官妍,王宁,汪长中,刘志芳,章九云,石晶金.穿心莲内酯等中药有效成分对表皮葡萄球菌生物膜渗透性的比较[J].中国微生态学杂志,2012,24(1):9-12. |
| |
| 作者姓名： | 官妍 王宁 汪长中 刘志芳 章九云 石晶金 |
| |
| 作者单位： | 1. 安徽中医学院,安徽合肥,230038
2. 蚌埠医学院,安徽蚌埠,233030 |
| |
| 基金项目： | 安徽省教育厅自然科学研究重点项目(KJ2010A214) |
| |
| 摘 要： | 目的比较穿心莲内酯、大黄素、盐酸小檗碱等对表皮葡萄球菌生物膜的渗透性，为中药治疗表皮葡萄球菌引起的相关感染提供相关研究的依据。方法在体外建立SE—BF（表皮葡萄球菌生物膜模型）和PB（生物膜渗透模型），观察穿心莲内酯、大黄素、盐酸小檗碱等中药有效成分对PB的渗透率。结果大黄素、穿心莲内酯36h渗透率分别达到88．00％、82．89％，而盐酸小檗碱渗透率在几种药物中相对较差。结论中药有效成分对表皮葡萄球菌生物膜有较强的渗透性。
|
| 关 键 词： | 穿心莲内酯 大黄素 盐酸小檗碱 表皮葡萄球菌 生物膜 渗透性 |
Comparison of Andrographolide and other active ingredients of Chinese herbal medicine in regard to Staphylococcus epidermidis biofilm permeability |
| |
| GUAN Yan
,
WANG Ning
,
WANG Chang-zhong
,
LIU Zhi-fang
,
ZHANG Jiu-yun
,
SHI Jing-jin.Comparison of Andrographolide and other active ingredients of Chinese herbal medicine in regard to Staphylococcus epidermidis biofilm permeability[J].Chinese Journal of Microecology,2012,24(1):9-12. |
| |
| Authors: | GUAN Yan WANG Ning WANG Chang-zhong LIU Zhi-fang ZHANG Jiu-yun SHI Jing-jin |
| |
| Institution: | 1.Anhui University of Traditional Chinese Medicine,Hefei 230038,China;2.Bengbu Medical College,Bengbu 233030,China) |
| |
| Abstract: | Objective To compare the permeability of andrographolide,emodin and berberine through Staphylococcus epidermidis biofilms,and provide a basis for treating infections caused by S.epidermidis.Method In vitro models of S.epidermidis biofilm(SE-BF) and penetration of biofilm(PB) were established,and the penetrating ratios of andrographolide,emodin and berberine were analyzed.Result The penetrating ratios of andrographolide and emodin for 36h were 82.89% and 88.00%,respectively,while that of berberine was lower than the other two.Conclusion These active ingredients of Chinese herbal medicine have a strong S.epidermidis biofilm permeability. |
| |
| Keywords: | Andrographolide Emodin Berberine Staphylococcus epidermidis Biofilms Permeability |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
