ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation |
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| Institution: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People''s Republic of China;2. State Key Laboratory of Phytochemistry and Plant Resourcese in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People''s Republic of China;3. School of Pharmacy, Dali University, Dali 671003, People''s Republic of China;4. Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technologynd Technology, Wuhan 430000, People''s Republic of China |
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| Abstract: | This work describes a novel ent-kaurane diterpene, ent-3β-hydroxy-kaur-16-en-19-al along with five known ent-kaurane diterpenes, ent-3β,19-dihydroxy-kaur-16-eno, ent-3β-hydroxy-kaur-16-eno, ent-3β-acetoxy-kaur-16-eno, ent-3β-hydroxy-kaurenoic acid and kaurenoic acid, as well as caryophyllene oxide, humulene epoxide II, β-sitosterol, stigmasterol and campesterol from the stem bark of Annona vepretorum Mart. (Annonaceae). Cytotoxic activities towards tumor B16-F10, HepG2, K562 and HL60 and non-tumor PBMC cell lines were evaluated for ent-kaurane diterpenes. Among them, ent-3β-hydroxy-kaur-16-en-19-al was the most active compound with higher cytotoxic effect over K562 cell line (IC50 of 2.49 μg/mL) and lower over B16-F10 cell line (IC50 of 21.02 μg/mL). |
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| Keywords: | Annonaceae Cytotoxicity |
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