Activity of caffeic acid derivatives against Candida albicans biofilm |
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| Institution: | 1. Department of Biological Sciences, State University of Santa Cruz, Rodovia Jorge Amado, Km-16, Salobrinho, 45662-900, Ilhéus, Bahia, Brazil;2. Department of Exact and Technological Sciences, State University of Santa Cruz, Rodovia Jorge Amado, Km-16, Salobrinho, 45662-900, Ilhéus, Bahia, Brazil;1. Laboratório de Microbiologia Médica, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del Rei, Divinópolis, Minas Gerais, Brazil;2. Laboratório de Biologia Molecular e Celular, Departamento de Química, Biotecnologia e Engenharia de Bioprocessos — Campus Alto Paraopeba, Universidade Federal de São João Del Rei, Ouro Branco, Minas Gerais, Brazil;3. Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil;4. Laboratório de Química de Produtos Naturais, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del Rei, Divinópolis, Minas Gerais, Brazil |
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| Abstract: | The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2–10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm.Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16 μg/mL, respectively, and in the early stage of biofilm formation (4 h) with MIC50 values of 64, 32 and 64 μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC50 values of 64 μg/mL. |
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| Keywords: | Caffeic acid Anti-biofilm agents Biofilm formation |
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