Antifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014

Vaginal Candidiasis is the most common and important opportunistic fungal infection in women. By increasing use of antifungaldrugs in recent years, it has caused drug resistance. This study aims to evaluate antifungal drugs susceptibility of Candida. sppisolated of women with vaginitis from Ilam-Iran during 2013-2014. samples were collected and cultured from 385 women withvaginitis, then Candida.spp was diagnosed by standard method. Antifungal drug susceptibility test for nystatin 100 unit/disk,fluconazole 10µg/disk, itraconazole 10µg/disk, ketoconazole 10µg/disk, amphotericinB 20µg/disk, clotrimazole 10µg/disk,posaconazole 5µg/disk, and voriconazole 1µg/disk were carried out by M44-A method(CLSI). From all culture positive samples,150 isolates were Candida albicans and 89 isolates were non-albicans. The resistance to fluconazole, itraconazole, ketoconazole,clotrimazole, voriconazole, posaconazole, nystatin and amphotericin B was 76%, 62%, 72%, 55%, 6%, 7%, 1% and 0%. The highestresistance was seen for fluconazole , itraconazole, and the highest susceptible was seen for nystatin and amphotericin B. Theseresults indicate nystatin and amphotericin B can be used as the first line for empirical therapy of vaginal candidiasis in the district.