Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity |
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| Affiliation: | 1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea;2. New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea;3. College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea;4. College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 420-743, Republic of Korea;1. Department of Pharmaceutical Science, Università degli Studi, Via Celoria 2, 20100 Milano, Italy;2. Department of Health Sciences, Università degli Studi, Via A. Di Rudinì 8, 20142 Milano, Italy;3. S. Paolo Hospital, Via A. Di Rudinì 8, 20142 Milano, Italy;1. Department of Chemistry, Middle Tennessee State University, 1301 Main St., Murfreesboro, TN, USA;2. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA;1. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan;2. Kyoto Prefectural University of Medicine, 13, Taishogun, Nishitakatsukasa-cho, Kita-ku, Kyoto 403-8334, Japan;3. School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan;1. Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke (Qc) J1H 5N4, Canada;2. SCF Pharma, Ste Luce (Qc) G0K 1P0, Canada |
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| Abstract: | Three new compounds (1–3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively. |
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| Keywords: | Flavonoid Arylbenzofruran Interleukin-6 Anti-allergy |
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