The use of human tissue in drug discovery |
| |
Authors: | Iain G Dougall |
| |
Institution: | (1) AstraZeneca R&D Charnwood, Bioscience Department, Bakewell Road, Loughborough, Leicestershire, LE11 5RH, UK |
| |
Abstract: | Experiments conducted on human tissue samples are a key component of modern drug discovery programs and complement the use
of animal tissue based assays in this process. Such studies can (i) enhance our understanding of disease pathophysiology,
(ii) increase (or decrease) confidence that modulating the function of particular molecular targets will have therapeutic
benefit (iii) allow comparison of the activities of different agents on particular mechanisms/processes and (iv) provide information
on the potential safety risks associated with targets. All of this information is critical in identifying the targets that
are most likely to deliver efficacious and safe medicines to address unmet clinical needs. With the introduction of new technologies,
human tissue samples are also increasingly being incorporated into drug project screening cascades, including their use in
high throughput assays. Improved access to human tissue would undoubtedly further extend the utility of this valuable resource
in the drug discovery process. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|