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DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications |
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| Authors: | Pierpaolo Falcicchio Suzanne Wolterink-Van Loo Maurice C. R. Franssen John van der Oost |
| Affiliation: | 1. Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703HB, Wageningen, The Netherlands 2. Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703HB, Wageningen, The Netherlands |
| Abstract: | Generating new carbon–carbon (C–C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C–C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed. |
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