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Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat |
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| Authors: | Hazel J. Hunt Nicholas C. Ray George Hynd Jon Sutton Mohammed Sajad Elizabeth O’Connor Shahadat Ahmed Peter Lockey Steve Daly Gerry Buckley Robin D. Clark Robert Roe Christine Blasey Joe Belanoff |
| Affiliation: | 1. Corcept Therapeutics, 149 Commonwealth Drive, Menlo Park, CA 94025, USA;2. Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, UK |
| Abstract: | We report the optimization of a series of non-steroidal GR antagonists that led to the identification of compound 7. This compound is efficacious when dosed orally in an olanzapine-induced weight gain model in rats. |
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