Antiproliferative activity of salinomycin and its derivatives |
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| Authors: | Adam Huczyński Jan Janczak Michał Antoszczak Joanna Wietrzyk Ewa Maj Bogumil Brzezinski |
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| Affiliation: | 1. Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland;2. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, PO Box 1410, 50-950 Wroc?aw, Poland;3. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroc?aw, Poland |
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| Abstract: | ![]()
Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin. |
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