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In vivo activity of an azole series of CCR2 antagonists |
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| Authors: | Chris A. Smethurst Nicola Bevan Carl Brooks Amanda Emmons Peter J. Gough Claudette Mookherjee Kitty Moores Simon Peace Joanne Philp Val Piercy Steve P. Watson Mara Zippoli |
| Affiliation: | 1. GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK;2. GlaxoSmithKline Research and Development, Upper Merion, PA, USA |
| Abstract: | Optimisation of a series of biaryl sulphonamides resulted in the identification of compound 7 which demonstrated dose-dependent and strain-specific inhibition of monocyte recruitment in a thioglycollate-induced peritonitis model of inflammation. |
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