Synthesis and anti-hyperglycemic activity of hesperidin derivatives |
| |
Authors: | Baoshun Zhang Tingting Chen Zhu Chen Mingxue Wang Dengyu Zheng Jinfeng Wu Xiaofei Jiang Xuegang Li |
| |
Institution: | 1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, PR China;2. Department of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing 400030, PR China |
| |
Abstract: | A series of hesperidin derivatives were prepared and identified by IR, 1H NMR, and MS spectra. These compounds were evaluated in vitro and in vivo based on α-glucosidase inhibition, glucose consumption of HepG2 cells, and blood glucose level in streptozotocin-induced diabetic mice. The results revealed that all the compounds exhibited anti-hyperglycemic activities. The inhibition at 10?3 M of compounds 3 and 7a on α-glucosidase were 55.02% and 53.34%, respectively, as compared to 54.80% by acarbose. Treated by compound 3 and the reference drug metformin, glucose consumption of HepG2 cell were 1.78 and 2.11 mM, respectively. After the streptozotocin-induced diabetic mice were oral administrated with compound 3 at 100 mg kg?1 d?1 for 10 days, the blood glucose level of 3 treated mice (13.23 mM, P <0.05) showed significant difference when compared to model control (23.03 mM). Thus, compound 3 exhibited promising anti-hyperglycemic activity. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|