Tryptophan phosphorescence signals characteristic changes in protein dynamics at physiological temperatures |
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| Authors: | Tölgyesi F Ullrich B Fidy J |
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| Affiliation: | Institute of Biophysics, Semmelweis University of Medicine, Puskin u. 9., Budapest, Hungary. tolgyesi@puskin.sote.hu |
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| Abstract: | The Arrhenius plot of the de-excitation rate of tryptophan triplet state deviates from linearity in the physiological temperature range for several proteins with buried tryptophans, similarly to the behaviour of enzyme activity. A model is presented featuring two de-excitation pathways whose effectiveness is regulated by protein dynamics. |
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