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Changes in Liver Proteome Expression of Senegalese Sole (Solea senegalensis) in Response to Repeated Handling Stress |
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| Authors: | Odete D. Cordeiro Tomé S. Silva Ricardo N. Alves Benjamin Costas Tune Wulff Nadège Richard Mahaut de Vareilles Luís E. C. Concei??o Pedro M. Rodrigues |
| Affiliation: | 1. Centro de Ciências do Mar do Algarve (CCMar), Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal 2. National Food Institute, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark 3. Centro Interdisciplinar de Investiga??o Marinha e Ambiental (CIIMAR) and Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Universidade do Porto, 4050-123, Porto, Portugal |
| Abstract: | The Senegalese sole, a high-value flatfish, is a good candidate for aquaculture production. Nevertheless, there are still issues regarding this species’ sensitivity to stress in captivity. We aimed to characterize the hepatic proteome expression for this species in response to repeated handling and identify potential molecular markers that indicate a physiological response to chronic stress. Two groups of fish were reared in duplicate for 28?days, one of them weekly exposed to handling stress (including hypoxia) for 3?min, and the other left undisturbed. Two-dimensional electrophoresis enabled the detection of 287 spots significantly affected by repeated handling stress (Wilcoxon–Mann–Whitney U test, p? |
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