Using the Internal Stress Concept to Assess the Importance of Moisture Sorption-induced Swelling on the Moisture Transport through the Glassy HPMC Films |
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Authors: | Fesia L Laksmana Paul J A Hartman Kok Henderik W Frijlink Herman Vromans Kees Van der Voort Maarschalk |
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Institution: | (1) Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands;(2) Department of Pharmaceutics, Schering–Plough Corporation, Oss, The Netherlands;(3) Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands;(4) PO BOX 20, Room RP2130, 5340 BH Oss, The Netherlands |
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Abstract: | The purpose of this research was to elucidate the significance of the changes in the mechanical and the volumetric properties
on the moisture diffusivity through the polymer films. The internal stress concept was adapted and applied to estimate the
relative impact of these property changes on the total stress experienced by a polymer film during storage. Hydroxypropyl
Methylcellulose free films were used as a model material prepared at various conditions and stored at different relative humidities.
The changes in the internal stress of these films due to the moisture sorption were studied. It was demonstrated that the
stress-relaxation of the films increases at increasing moisture content. At the point when there is a definite loss of stress
in the film, which is at moisture content higher than 6%, was shown to correlate with the significant increase of the moisture
diffusivity. Further investigations revealed that the loss of stress is especially due to the swelling of the polymer rather
than the changes in the inherent strain (the quotient between the tensile strength and the modulus of elasticity) of the HPMC
films. This implies that the impact of the moisture sorption on the diffusivity is predominantly via volume addition rather than via altering the mechanical properties. Additionally, the approach presented here also brings up a new application of the internal
stress concept, which in essence suggests the possibility to estimate the diffusion coefficient from the sorption isotherm
and the mechanical analysis data. |
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Keywords: | HPMC internal stress mechanical properties moisture diffusion swelling |
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