Convenient synthesis of GOLD and MOLD and identification of their oxidation products in vitro and in vivo |
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Authors: | M D Linetsky E V Shipova |
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Institution: | (1) Mason Eye Institute, University of Missouri-Columbia, Columbia, Missouri, U.S.A. |
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Abstract: | Summary. Two Lys–Lys crosslinks, 1,3-bis-(5-amino-5-carboxypentyl)-1H-imidazolium (GOLD) and 1,3-bis(5-amino-5-carboxypentyl)-4-methyl-1H-imidazolium
(MOLD) salts, have been synthesized by the reaction of imidazole or 4(5)-methyl imidazole with 5-(4-bromobutyl)-hydantoin
followed by the hydrolysis of 1,3-substituted imidazolium derivatives by 6.0 N HCL at 110 °C. Treatment of GOLD and MOLD with
hydrogen peroxide in acetic acid leads to MOLD oxidation only. The oxidation product of MOLD was detected in cataractous lens
proteins. |
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Keywords: | : Advanced Glycation End Products (AGEs) – GOLD – Lysine crosslinks – Maillard reaction – MOLD |
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