Effect of antagonists of serotonin receptors on modulation with serotonin of synaptic activity of projectional neurons of rat amygdala dorsolateral nucleus |
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| Authors: | I S Masalov E A Tsvetkov E I Lokshina N P Vesselkin |
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| Institution: | 1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia
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| Abstract: | The work studies role of different receptor types of serotonin (5-hydroxytryptamine; 5-HT) in the process of synaptic activity modulation with 5-HT of rat dorsolateral amygdala projection neurons. The selective antagonist of 5-HT1,2 receptors methylsergid maleate was shown to suppress the 5-HT inhibitory action on amplitude of the postsynaptic currents evoked by glutamate and GABA, whereas the antagonist of 5-HT3,4 receptors SDZ202-557 produced no effect on the above-mentioned 5-HT action. The obtained action indicates that the 5-HT modulatory effect on the projectional neuron synaptic inputs is mediated by 5-HT receptors of the 1 and 2 types. |
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