Myosins and membrane trafficking in intestinal brush border assembly |
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| Affiliation: | 1. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany;2. Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität, Dresden, Germany;1. Department of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA;2. Department of Radiation Oncology, Dana-Farber Brigham Cancer Center, 75 Francis St, Boston, MA 02115, USA;3. Ludwig Center at Harvard, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215, USA;1. Department of Medicine (Nephrology Division), Washington University, St Louis, MO, USA;2. Department of Cell Biology and Physiology, Washington University, St Louis, MO, USA;1. Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands;2. Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia;1. Laboratory for Cell Systems, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan;2. Center for Drug Design and Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, 567-0085, Japan;1. Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA;2. IFOM, FIRC Institute of Molecular Oncology, Milan, 20139, Italy |
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| Abstract: | ![]()
Myosins are a class of motors that participate in a wide variety of cellular functions including organelle transport, cell adhesion, endocytosis and exocytosis, movement of RNA, and cell motility. Among the emerging roles for myosins is regulation of the assembly, morphology, and function of actin protrusions such as microvilli. The intestine harbors an elaborate apical membrane composed of highly organized microvilli. Microvilli assembly and function are intricately tied to several myosins including Myosin 1a, non-muscle Myosin 2c, Myosin 5b, Myosin 6, and Myosin 7b. Here, we review the research progress made in our understanding of myosin mediated apical assembly. |
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