基于模板的蛋白质结构预测

基于模板的蛋白结构预测和不依赖模板的蛋白结构预测是计算预测蛋白质三维结构的两种方法,前者由于具有快速和较高准确性的优点,而得到了广泛的应用.基于模板的结构预测是通过寻找与目标蛋白序列相似并且有实验测定的结构作为模板,进而构建目标序列的结构模型的方法.文章详细综述了基于模板的结构预测方法的步骤、关键环节,并对影响结构预测...

Template-Based Protein Structure Prediction

Methods for predicting three-dimensional structure of protein molecules can be classified into two categories: template-based modeling and template free modeling. Template-based prediction is widely used in application due to its speed and relatively high accuracy. This technique predicts the three-dimensional structure of a given protein sequence based primarily on its alignment to one or more proteins of known structure. In this paper, the progress in the methodology for template-based modeling is reviewed. The critical steps and factors that influence the prediction accuracy are analysed and discussed.