New Views of Old Proteins: Clarifying the Enigmatic Proteome |
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| Authors: | Kristin E. Burnum-Johnson Thomas P. Conrads Richard R. Drake Amy E. Herr Ravi Iyengar Ryan T. Kelly Emma Lundberg Michael J. MacCoss Alexandra Naba Garry P. Nolan Pavel A. Pevzner Karin D. Rodland Salvatore Sechi Nikolai Slavov Jeffrey M. Spraggins Jennifer E. Van Eyk Marc Vidal Christine Vogel Neil L. Kelleher |
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| Affiliation: | 1. The Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA;2. Inova Women’s Service Line, Inova Health System, Falls Church, Virginia, USA;3. Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, USA;4. Department of Bioengineering, University of California, Berkeley, California, USA;5. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA;6. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA;7. Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden;8. Department of Genome Sciences, University of Washington, Seattle, Washington, USA;9. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA;10. Department of Pathology, Stanford University, Stanford, California, USA;11. Department of Computer Science and Engineering, University of California at San Diego, San Diego, California, USA;12. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA;13. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA;14. Department of Bioengineering, Northeastern University, Boston, Massachusetts, USA;15. Department of Cell and Developmental Biology, Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA;16. Advanced Clinical Biosystems Institute in the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA;17. Department of Genetics, Harvard University, Cambridge, Massachusetts, USA;18. New York University Center for Genomics and Systems Biology, New York University, New York, New York, USA;19. Department of Pathology, Harvard Medical School, Brigham and Women’s Hospital, Wyss Institute at Harvard University, Boston, Massachusetts, USA;20. Department of Chemistry, Northwestern University, Evanston, Illinois, USA |
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| Abstract: | All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade. |
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| Keywords: | proteins proteomics single-cell biology biotechnology single-molecule sequencing ECM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" extracellular matrix HuBMAP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Human BioMolecular Atlas Program MS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" mass spectrometry PTM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" post-translational modification |
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