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New Views of Old Proteins: Clarifying the Enigmatic Proteome
Authors:Kristin E. Burnum-Johnson  Thomas P. Conrads  Richard R. Drake  Amy E. Herr  Ravi Iyengar  Ryan T. Kelly  Emma Lundberg  Michael J. MacCoss  Alexandra Naba  Garry P. Nolan  Pavel A. Pevzner  Karin D. Rodland  Salvatore Sechi  Nikolai Slavov  Jeffrey M. Spraggins  Jennifer E. Van Eyk  Marc Vidal  Christine Vogel  Neil L. Kelleher
Affiliation:1. The Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA;2. Inova Women’s Service Line, Inova Health System, Falls Church, Virginia, USA;3. Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, USA;4. Department of Bioengineering, University of California, Berkeley, California, USA;5. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA;6. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA;7. Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden;8. Department of Genome Sciences, University of Washington, Seattle, Washington, USA;9. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA;10. Department of Pathology, Stanford University, Stanford, California, USA;11. Department of Computer Science and Engineering, University of California at San Diego, San Diego, California, USA;12. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA;13. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA;14. Department of Bioengineering, Northeastern University, Boston, Massachusetts, USA;15. Department of Cell and Developmental Biology, Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA;16. Advanced Clinical Biosystems Institute in the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA;17. Department of Genetics, Harvard University, Cambridge, Massachusetts, USA;18. New York University Center for Genomics and Systems Biology, New York University, New York, New York, USA;19. Department of Pathology, Harvard Medical School, Brigham and Women’s Hospital, Wyss Institute at Harvard University, Boston, Massachusetts, USA;20. Department of Chemistry, Northwestern University, Evanston, Illinois, USA
Abstract:All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.
Keywords:proteins  proteomics  single-cell biology  biotechnology  single-molecule sequencing  ECM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  extracellular matrix  HuBMAP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Human BioMolecular Atlas Program  MS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  mass spectrometry  PTM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  post-translational modification
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