| 天然抗感染分子-细菌透性增加蛋白 |
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| 引用本文： | 马海蓉,孙仪,曹旭,汪汉卿.天然抗感染分子-细菌透性增加蛋白[J].中国生物工程杂志,2006,26(7):94-98. |
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| 作者姓名： | 马海蓉 孙仪 曹旭 汪汉卿 |
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| 作者单位： | 中科院物物理化学研究所 中科院新疆理化技术研究所 中科院新疆理化技术研究所 中科院物物理化学研究所 |
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| 基金项目： | 中国科学院"百人计划" |
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| 摘 要： | 革兰氏阴性菌细胞外壁中的脂多糖结构即内毒素,经常是引发脓毒症、菌血症等系统性炎症反应的"元凶"。近十余年的研究发现,细菌透性增加蛋白（bactericidal/permeability-increasing protein,BPI）具有特有的中和内毒素和拮抗革兰氏阴性菌的能力, 是一种抗感染的天然的分子靶。大量的临床研究结果已经显示其用药的有效性和安全性。近几年来国外生物药业公司正努力将重组人BPI推向市场。
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| 关 键 词： | 脓毒症 脂多糖 细菌透性增加蛋白 内毒素 |
| 收稿时间： | 2006-01-04 |
| 修稿时间： | 2006-04-17 |
Natural Anti-infectious Molecule: Bactericidal/ permeability- increasing Protein |
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| MA Hai-rong, SUN Yi, CAO Xu,WANG Han-qing.Natural Anti-infectious Molecule: Bactericidal/ permeability- increasing Protein[J].China Biotechnology,2006,26(7):94-98. |
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| Authors: | MA Hai-rong SUN Yi CAO Xu WANG Han-qing |
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| Institution: | 1.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences Lanzhou 730000, China; 2. Xingjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China; 3. Postgraduate School, Chinese Academy of Sciences Beijing 100049, China |
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| Abstract: | Endotoxins are lipopolysaccharides ( LPS) , major component of out wall in Gram-negative bacteria. Often they are considered as "prime criminals" of triggering systemic inflaming reaction such as sepsis, bacteremia and so on. It was found in recent years that bactericidal/permeability-increasing protein, a 55kDa member of lipid-related protein family, was a kind of natural molecule of anti-infection and it has special endotoxin-neutralising activity and antibacterial activity. Comprehensive phase II/III clinical trials demonstrated the feasibility and safety of recombinant BPI. So pharmaceutical corporations are attracted to try to apply it to therapy. |
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| Keywords: | Bactericidal/permeability-increasing protein Endotoxin Immunity Sepsis Lipopolysaccharide |
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