Quantitation of dexamethasone in biological fluids using high-performance liquid chromatography |
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| Authors: | S.Edmund Tsuei John J. Ashley R.George Moore William G. McBride |
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| Affiliation: | Department of Pharmacy, University of Sydney, N.S.W. 2006 Australia;Foetal Pharmacology Laboratory, Foundation 41, The Women''s Hospital Crown Street, Sydney, N.S.W. 2010 Australia |
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| Abstract: | A sensitive and specific method for the quantitation of dexamethasone in plasma and urine is described. The specificity of the method is obtained using adsorption chromatography on a high-performance liquid chromatograph. The dexamethasone is detected with a variable-wavelength UV detector. An internal standard technique is used for quantitation of dexamethasone with a minimum sensitivity of 15 ng. Preliminary results of the application of the method to pharmacokinetic studies of dexamethasone in humans are reported. |
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| Keywords: | To whom reprint requests are to be sent |
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