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2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution |
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| Authors: | Cooper L C Chicchi G G Dinnell K Elliott J M Hollingworth G J Kurtz M M Locker K L Morrison D Shaw D E Tsao K L Watt A P Williams A R Swain C J |
| Affiliation: | Department of Medicinal Chemistry, The Neuroscience Research Centre, Harlow, Essex, UK. laura_cooper@merck.com |
| Abstract: |  The synthesis and biological evaluation of a series of 2-aryl indoles with high affinity for the human neurokinin-1 (hNK1) receptor are reported, concentrating on optimisation of the indole substitution. |
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