| 乳腺癌耐药蛋白介导多重耐药机制及其逆转 |
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| 引用本文： | 王永仿,窦骏. 乳腺癌耐药蛋白介导多重耐药机制及其逆转[J]. 生物技术通讯, 2006, 17(4): 634-636 |
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| 作者姓名： | 王永仿 窦骏 |
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| 作者单位： | 东南大学,病原生物学与免疫学系,江苏,南京,210009 |
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| 基金项目： | 江苏省卫生厅资助项目(H200541) |
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| 摘 要： | 近年发现的乳腺癌耐药蛋白属于ATP结合框转运体家族中的G亚家族,是主要的介导肿瘤细胞多药耐药机制的跨膜转运蛋白之一,在临床抗肿瘤治疗中具有重要的意义。本文综述了乳腺癌耐药蛋白的结构特点、表达特征,及其介导的肿瘤细胞多重耐药机制与逆转等方面的研究进展,并展望了今后的研究方向。
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| 关 键 词： | 乳腺癌耐药蛋白 多药耐药 半转运体 |
| 文章编号： | 1009-0002(2006)04-0634-03 |
| 收稿时间： | 2005-10-26 |
| 修稿时间： | 2005-10-26 |
Mechanism of Breast Cancer Resistance Protein Mediated Multidrug Resistance and its Conversion |
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| WANG Yong-fang,DOU Jun. Mechanism of Breast Cancer Resistance Protein Mediated Multidrug Resistance and its Conversion[J]. Letters in Biotechnology, 2006, 17(4): 634-636 |
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| Authors: | WANG Yong-fang DOU Jun |
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| Affiliation: | Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China |
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| Abstract: | Breast cancer resistance protein(BCR P)was discovered in recent years,which is a m em ber of G subfam ily in ATP-binding cassette transporter fam ily.As a m ain trans-m em brance transport protein,it m ediates m ultidrug resistance(M DR) in tum or cells and plays an im portant role in clinic antitum or therapy.It was reviewed in this paper that the BCRP have the characteristics of structure and expression and its m echanism of M DR in tum or cells as well as the con-version of M DR.The developm ent of the field in future was also included in the review. |
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| Keywords: | breast cancer resistance protein m ultidrug resistance half-transporter |
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