Crosstalk between TNF and glucocorticoid receptor signaling pathways |
| |
| Authors: | Tom Van Bogaert Karolien De Bosscher Claude Libert |
| |
| Affiliation: | 1. Department of Biomedical Molecular Biology, Ghent University, Belgium;2. Department for Molecular Biomedical Research, VIB, Ghent, Belgium;3. Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, Belgium;1. Department of Pathology, University of Miami-Miller School of Medicine, Miami, FL, USA;2. Laboratory for Clinical and Biological Studies, University of Miami-Miller School of Medicine, Miami, FL, USA;3. Department of Psychiatry and Behavioral Science, University of Miami-Miller School of Medicine, Miami, FL, USA;1. Department of Microbiology, The University of Iowa, USA;2. The Graduate Program in Immunology, The University of Iowa, USA;3. Department of Internal Medicine, The University of Iowa, USA;4. Veterans Affairs Medical Center, Iowa City, IA 52242, USA;3. Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Alberta T2N 4Z6, Canada;4. Arnie Charbonneau Cancer Institute, Department of Oncology, University of Calgary, Alberta T2N 4Z6, Canada;5. Faculty of Science, Sohag University, Sohag 82524, Egypt;6. Department of Medicine, National Jewish Health, Denver, Colorado 80206;1. Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, B9052 Ghent, Belgium;2. Department of Biomedical Molecular Biology, Ghent University, B9052 Ghent, Belgium |
| |
| Abstract: | ![]()
TNF is a Janus-faced protein. It possesses impressive anti-tumor activities, but it is also one of the strongest known pro-inflammatory cytokines, which hampers its use as a systemic anti-cancer agent. TNF has been shown to play a detrimental role in inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Glucocorticoids are strongly anti-inflammatory and exert their therapeutic effects through binding to their receptor, the glucocorticoid receptor. Therefore, glucocorticoids have been used for over half a century for the treatment of inflammatory diseases. However, many patients are or become resistant to the therapeutic effects of glucocorticoids. Inflammatory cytokines have been suggested to play an important role in this steroid insensitivity or glucocorticoid resistance. This review aims to highlight the mechanisms of mutual inhibition between TNF and GR signaling pathways. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
