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RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
Authors:Gianmaria Liccardi  Laura Ramos Garcia  Tencho Tenev  Alessandro Annibaldi  Arnaud J Legrand  David Robertson  Rebecca Feltham  Holly Anderton  Maurice Darding  Nieves Peltzer  Marius Dannappel  Hannah Schünke  Luca L Fava  Manuel D Haschka  Timo Glatter  Alexey Nesvizhskii  Alexander Schmidt  Philip A Harris  Pascal Meier
Institution:1. The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK;2. The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia;3. Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College, London WC1E 6BT, UK;4. Institute for Genetics, Centre for Molecular Medicine (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany;5. Division of Dev. Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, A-6020, Austria;6. Proteomics Core Facility, Biocentrum of the University of Basel, Basel, Switzerland;7. Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043 Marburg, Germany;8. Department of Pathology, Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA;9. Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA;10. Tyrolean Cancer Research Institute, A-6020 Innsbruck, Austria;11. Barts Cancer Institute, Queen Mary, John Vane Science Centre, University of London, Charterhouse Square, London EC1M 6BQ, UK
Abstract:
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  • Keywords:RIPK1  caspase-8  cell death  cell cycle  mitosis  PLK1  BUBR1  chromosomal instability  ripoptosome  cancer
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