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Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study |
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| Authors: | Linda van Wyk Jacolien van der Marel Annemie JM Schuerwegh Anne A Schouffoer Alexandre E Voskuyl Tom WJ Huizinga Diana W Bianchi Sicco A Scherjon |
| Affiliation: | (1) Department of Obstetrics, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, PO BOX 9600, 2300 RC Leiden, The Netherlands;(2) Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, PO BOX 9600, 2300 RC Leiden, The Netherlands;(3) Department of Rheumatology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;(4) Department of Pediatrics, Floating Hospital for Children at Tufts Medical Centre, 755 Washington Street, Boston, MA 02111, USA |
| Abstract: | IntroductionStudies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such as hypertension, preeclampsia, miscarriage and intra-uterine growth restriction (IUGR). Women with these pregnancy complications are significantly more often HLA-class II compatible with their spouses. Women who later develop scleroderma also give birth to an HLA-class II child more often. From these prior studies we hypothesized that preeclampsia and other pregnancy complications could be associated with increased levels of fetal cell trafficking, and later be involved in the development of scleroderma. |
| Keywords: | Pregnancy Chimerism Systemic sclerosis Hypertension Pre-eclampsia Intra-uterine growth restriction |
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