Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila |
| |
| Authors: | Haiwei Pi Yi-Chun Huang I-Chun Chen Chung-De Lin Hsiao-Fong Yeh Li-Mei Pai |
| |
| Affiliation: | (1) Department of Biomedical Sciences, School of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan;(2) Graduate Institute of Biomedical Sciences, School of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan |
| |
| Abstract: | Background The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great interest to look for anti-Notch reagents for therapeutic purposes. In model animal Drosophila, Notch signaling restricts selection of sensory organ precursors (SOPs) during external sensory (ES) organ development. To look for novel genes that can suppress Notch signaling, we performed a gain-of-function modifier screen to look for genes that enhance the phenotype of ectopic ES organs induced by overexpression of phyllopod, a gene required for SOP specification. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
