| 冻伤对大鼠血凝系统某些因素的影响 |
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| 引用本文： | 李凤芝,颜培华.冻伤对大鼠血凝系统某些因素的影响[J].中国应用生理学杂志,1995,11(1):60-63. |
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| 作者姓名： | 李凤芝 颜培华 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所 |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 本研究观察了大鼠双后足局部冻伤后其血凝系统某些因素的改变。结果表明，冻伤后大鼠的出血时间及凝血时间明显缩短，血小板数增加，血小板聚集率增高，血浆血栓素Ａ２、纤维蛋白原及钙离子浓度均明显增加，且上述指标的改变与冻伤程度有密切关系，冻伤愈重，改变愈明显，恢复亦愈慢。结果提示，冻伤可使血凝系统发生改变，血液处于高凝状态，这对浆伤后发生的血液循环障碍最终导致冻伤组织坏死的病理过程起重要作用。
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| 关 键 词： | 冻伤 血液凝固 血液循环障碍 |
THE EFFECTS OF FROSTBITE ON SOMEFACTORS OF BLOOD COAGULATION
SYSTEMINRATS |
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| Li Fengzhi,Yan Peihua,Liu Youmei,Zhang
Shijing.THE EFFECTS OF FROSTBITE ON SOMEFACTORS OF BLOOD COAGULATION
SYSTEMINRATS[J].Chinese Journal of Applied Physiology,1995,11(1):60-63. |
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| Authors: | Li Fengzhi Yan Peihua Liu Youmei Zhang
Shijing |
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| Abstract: | The changes of some
factors of the blood coagulation system in rats following cold in
jury ofboth hind feet were investigated.The results showed that the
bleeding time and clotting time wereshortened;the platelet count was
increased;the rate of platelet aggregation,the contents ofthromboxine
and fibrinogen,and the calcium concentration were enhanced.These
changes wereclosely related to the degree of frostbite. It is
suggested that the blood coagulability can be affect-ed by cold
injury,leading to the dysfunction of circulation and necrosis of
local frostbitten tissue-ultimately. |
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| Keywords: | frostbite blood coagulability dysfunction of circulation |
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