Characterization of MRNP34, a novel methionine-rich nacre protein from the pearl oysters |
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Authors: | Benjamin Marie Caroline Joubert Corinne Belliard Alexandre Tayale Isabelle Zanella-Cléon Frédéric Marin Yannick Gueguen Caroline Montagnani |
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Institution: | 1.Ifremer, LBQP,Centre Océanologique du Pacifique,Taravao,French Polynesia;2.UMR 5561, CNRS, Biogéosciences,Université de Bourgogne,Dijon,France;3.UMR 7245, CNRS, MCAM,Muséum National d’Histoire Naturelle,Paris,France;4.UMR 5086, CNRS, IFR 128?BioSciences, IBCP,Université de Lyon 1,Lyon,France;5.UMR 5119, CNRS, Ifremer, IRD, Ecologie des Systèmes Marins C?tiers,Université Montpellier II,Montpellier,France |
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Abstract: | Nacre of the Pinctada pearl oyster shells is composed of 98% CaCO3 and 2% organic matrix. The relationship between the organic matrix and the mechanism of nacre formation currently constitutes
the main focus regarding the biomineralization process. In this study, we isolated a new nacre matrix protein in P. margaritifera and P. maxima, we called Pmarg- and Pmax-MRNP34 (methionine-rich nacre protein). MRNP34 is a secreted hydrophobic protein, which is remarkably rich in methionine,
and which is specifically localised in mineralizing the epithelium cells of the mantle and in the nacre matrix. The structure
of this protein is drastically different from those of the other nacre proteins already described. This unusual methionine-rich
protein is a new member in the growing list of low complexity domain containing proteins that are associated with biocalcifications.
These observations offer new insights to the molecular mechanisms of biomineralization. |
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