| 杆状病毒作为基因治疗载体的研究进展 |
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| 引用本文： | 梁昌镛,胡志红,陈新文.杆状病毒作为基因治疗载体的研究进展[J].生物化学与生物物理进展,2002,29(6):860-862. |
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| 作者姓名： | 梁昌镛 胡志红 陈新文 |
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| 作者单位： | 中国科学院武汉病毒研究所,无脊椎动物病毒学联合开放实验室,武汉,430071 |
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| 基金项目： | 国家自然科学基金资助项目（30070034，30025003）和中国科学院知识创新工程方向性项目（kscx2-sw-302）. |
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| 摘 要： | 杆状病毒是昆虫专一性的病原病毒.近来的研究表明杆状病毒能进入哺乳动物细胞, 但病毒自身不能在哺乳动物细胞中复制, 感染也不引起细胞病变.另外，已经证明杆状病毒能在体外或体内高效地转导许多类型哺乳动物细胞，并且能得到固定表达细胞系，显示了杆状病毒作为基因治疗载体有着良好的应用前景.综述了该领域的最新研究进展并探讨了其发展趋势.
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| 关 键 词： | 杆状病毒，基因治疗，基因治疗载体，转导 |
| 收稿时间： | 2002/5/10 0:00:00 |
| 修稿时间： | 2002年5月10日 |
The Development of Baculoviruses as Novel Gene Therapy Vectors |
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| LIANG Chang-Yong,HU Zhi-Hong and CHEN Xin-Wen.The Development of Baculoviruses as Novel Gene Therapy Vectors[J].Progress In Biochemistry and Biophysics,2002,29(6):860-862. |
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| Authors: | LIANG Chang-Yong HU Zhi-Hong and CHEN Xin-Wen |
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| Institution: | Joint-laboratory of Invertebrate Virology, Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan 430071, China;Joint-laboratory of Invertebrate Virology, Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan 430071, China;Joint-laboratory of Invertebrate Virology, Wuhan Institute of Virology, The Chinese Academy of Sciences, Wuhan 430071, China |
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| Abstract: | Baculoviruses are host specific for insects. The recent researches indicated that baculoviruses could entry into different mammalian cells, but do not replicate. The baculoviruses have been successfully used to deliver foreign DNA into mammalian cells in vitro and in vivo and efficiently mediated the expression of interest genes. These results indicated that baculovirus could be developed as potential gene therapy vectors. The recent development and prospects on using baculoviruses as target gene delivered vectors in gene therapy is reviewed. |
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| Keywords: | baculovirus gene therapy gene therapy vector transduction |
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