Frequency,Suppressive Capacity,Recruitment and Induction Mechanisms of Regulatory T Cells in Sinonasal Squamous Cell Carcinoma and Nasal Inverted Papilloma |
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Authors: | Hongfei Lou Jugao Fang Pingdong Li Weiguo Zhou Yang Wang Erzhong Fan Ying Li Hong Wang Zhongyan Liu Lei Xiao Chengshuo Wang Luo Zhang |
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Institution: | 1Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, PR China;2Beijing Key Laboratory of nasal diseases, Beijing Institute of Otolaryngology, Beijing, PR China;3Sections of Pulmonary & Cardiology, University of Illinois at Chicago, Chicago, Illinois, United States of America;Rutgers - New Jersey Medical School, UNITED STATES |
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Abstract: | BackgroundSinonasal squamous cell carcinoma (SSCC) and nasal inverted papilloma (NIP) represent the predominant type of malignant and benign tumors in sinonasal tract, respectively. CD4+CD25+Foxp3+ natural regulatory T (Treg) cells might play critical role(s) in the suppression of anti-tumor immune response and thus shed light on tumor progression from benign to malignant.ObjectiveThis study aimed to evaluate the frequency and suppressive capacity of Treg cells in SSCC compared to NIP and further to explore the underlying mechanisms.ResultsTumor-infiltrating Treg cells increased significantly from normal to NIP to SSCC (P ≤ 0.001 for normal vs. NIP and P = 0.004 for NIP vs. SSCC). Significantly elevated frequency and enhanced suppression capacity of circulating Treg cells in SSCC were detected compared to NIP and healthy controls, concomitant with Th1 decrease and Th2 increase. Apparently increased CCL22 attracted CCR4-expressing Treg cells to tumor microenvironment in SSCC, compared to NIP. SSCC produced significantly more TGF-β than NIP and thus possessed greater potential for Treg cell induction.ConclusionFrequency and suppressive capacity of Treg cells enhanced with progression of malignancy from NIP to SSCC. Circulating Treg cells were recruited to tumor tissue via CCR4/CCL22 signalling, whereas tumor-synthesised TGF-β contributed to induction of peripheral Treg cells. |
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