Hitchhiking and associative overdominance at a microsatellite locus |
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Authors: | Slatkin M |
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Institution: | Department of Integrative Biology, University of California at Berkeley, 94720, USA. |
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Abstract: | The possible effects of a selected locus on a closely linked microsatellite
locus are discussed and analyzed in terms of coalescent theory and models
of the mutation process. Background selection caused by recurrent
deleterious mutations will reduce the variance of allele size at a
microsatellite locus. The occasional substitution of advantageous alleles
(genetic hitchhiking) will also reduce the variance, but a high mutation
rate at a microsatellite locus can restore the variance relatively rapidly.
Overdominance at the selected locus will increase the variance at the
microsatellite locus and create partitioning of the variation in allele
size among gametes carrying one or the other of the overdominant alleles.
These results suggest that neutral microsatellite loci can provide
indicators of selective processes at closely linked loci.
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Keywords: | |
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