The tendency to recreate ancestral CG dinucleotides in the human genome |
| |
| Authors: | Mingkun Li and Su-Shing Chen |
| |
| Institution: | (1) CAS-MPG Partner Institute of Computational Biology, Chinese Academy of Sciences, Shanghai Institutes of Biological Sciences, 200000 Shanghai, PR China;(2) Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D04103 Leipzig, Germany |
| |
| Abstract: | Background The CG dinucleotides are known to be deficient in the human genome, due to a high mutation rate from 5-methylated CG to TG
and its complementary pair CA. Meanwhile, many cellular functions rely on these CG dinucleotides, such as gene expression
controlled by cytosine methylation status. Thus, CG dinucleotides that provide essential functional substrates should be retained
in genomes. How these two conflicting processes regarding the fate of CG dinucleotides - i.e., high mutation rate destroying
CG dinucleotides, vs. functional processes that require their preservation remains an unsolved question. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
