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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ |
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| Authors: | Lloyd G. Czaplewski Ian Collins E. Andrew Boyd David Brown Stephen P. East Mihaly Gardiner Rowena Fletcher David J. Haydon Vincent Henstock Peter Ingram Clare Jones Caterina Noula Leanne Kennison Chris Rockley Valerie Rose Helena B. Thomaides-Brears Rebecca Ure Mark Whittaker Neil R. Stokes |
| Affiliation: | 1. Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK;2. Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, UK;3. Key Organics Ltd, Highfield Industrial Estate, Camelford, Cornwall PL32 9QZ, UK |
| Abstract: | 3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure–activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds. |
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