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Adjuvant properties of a simplified C32 monomycolyl glycerol analogue |
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| Authors: | Veemal Bhowruth David E Minnikin Else Marie Agger Peter Andersen Vincent W Bramwell Yvonne Perrie Gurdyal S Besra |
| Institution: | 1. School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK;2. Department of Infectious Disease Immunology, Adjuvant Research, Statens Serum Institut, Copenhagen 2300, Denmark;3. School of Life and Health Sciences Aston University, Aston Triangle, Birmingham B4 7ET, UK |
| Abstract: | A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-γ and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6′-di-behenate (TDB). |
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