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Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR,synthesis and biological evaluation |
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| Authors: | Janet L. Ralbovsky Joseph G. Lisko Jeffrey M. Palmer John Mabus Kristen M. Chevalier Mark J. Schulz Alexey B. Dyatkin Tamara A. Miskowski Steven J. Coats Pamela Hornby Wei He |
| Affiliation: | Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, L. L. C., Welsh and McKean Rds., Spring House, PA 19477, United States |
| Abstract: | A series of guanidine triazinediones were identified as potent PK1 receptor antagonists. A compound in this series inhibited the PK1 invoked prosecretory response in rat ileum tissue. |
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