TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina |
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| Authors: | Masaaki Ozawa Tadahiro Etoh Masahiko Hayashi Kanki Komiyama Akio Kishida Ayumi Ohsaki |
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| Institution: | 1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Surugadai, Kanda, Chiyoda-ku, Tokyo 101-0062, Japan;2. Iwaki Meisei University, 5-5-1, Iino, Chuo-dai, Iwaki, Fukushima 970-8551, Japan;3. The Kitasato Institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan |
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| Abstract: | A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2–7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL. |
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