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Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline |
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| Authors: | Qian Wu Joanne M. Caine Stuart A. Thomson Meri Slavica Gary L. Grunewald Michael J. McLeish |
| Affiliation: | 1. College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA;2. Victorian College of Pharmacy, Monash University, Parkville 3052, Australia;3. Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA |
| Abstract: | Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT. |
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