Repenins A–D,four new antioxidative coumarinolignoids from Duranta repens Linn. |
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| Authors: | Nisar Ahmad Fozia Zeb Ijaz Ahmad Fanghai Wang |
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| Institution: | 1. Department of Plant Sciences, Kohat University of Science and Technology, Kohat-26000, N.W.F.P., Pakistan;2. Kohat Institute of Medical Sciences, Kohat University of Science and Technology, Kohat-26000, N.W.F.P., Pakistan;3. Department of Chemistry, Kohat University of Science and Technology, Kohat-26000, N.W.F.P., Pakistan;4. Department of Biological Sciences, University of Zhongshan, Guangzhou-510275, China |
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| Abstract: | Phytochemical investigations on the CHCl3-soluble fraction of the whole plant of Duranta repens Linn. led to the isolation of four new coumarinolignoids, Repenins A–D (1–4), along with the known coumarinolignoids, cleomiscosin A (5) and durantin A (6). Their structures were determined by modern spectroscopic analysis including 1D and 2D NMR techniques and chemical studies. The compounds (1–6) showed potent antioxidative scavenging activity against DPPH radicals, with IC50 values in the range 0.420–0.625 mM. Repenin B (2) displayed the strongest scavenging potential with IC50 values of (0.420 mM). |
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