[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain |
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| Authors: | Kazuhiko Yanamoto Katsushi Kumata Tomoteru Yamasaki Chika Odawara Kazunori Kawamura Joji Yui Akiko Hatori Kazutoshi Suzuki Ming-Rong Zhang |
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| Institution: | Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan |
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| Abstract: | 18F]FEAC (18F]4a) and 18F]FEDAC (18F]4b) were developed as two novel positron emission tomography (PET) ligands for peripheral-type benzodiazepine receptor (PBR). 18F]4a and 18F]4b were synthesized by fluoroethylation of precursors 8a and 8b with 18F]FCH2CH2Br (18F]9), respectively. Small-animal PET scan for a neuroinflammatory rat model showed that the two radioligands had high uptakes of radioactivity in the kainic acid-infused striatum, a brain region where PBR density was increased. |
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