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Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation |
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| Authors: | Junqing Guo Andrew Watson James Kempson Marianne Carlsen Joseph Barbosa Karen Stebbins Deborah Lee John Dodd Steven G. Nadler Murray McKinnon Joel Barrish William J. Pitts |
| Affiliation: | Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA |
| Abstract: | A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure–activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition. |
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